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This work was done by preparing specifically designed cigarettes and THS tobacco sticks in a way that would avoid confounding factors: The test products were prepared using the same tobacco blend Tobacco from the same crops was used to eliminate differences caused by agricultural variability No flavors were added to either of the test products Distribution of yield ratios of all analytical features (chemical signals of different masses) detected in both THS and cigarette (bar height indicates the number of features within a given logarithmic yield ratio interval)