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"Risk factors for nasal malignancies in German men: The South-German Nasal cancer study"

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The malignant potential of leukoplakia patches relies on the size, location, type of leukoplakia, and associated risk factors like smoking and alcohol

Toxic components and bacteria in cigarette impact oral bacteria directly or indirectly through immunosuppression, oxygen deprivation, biofilm formation, or other potential mechanisms [49], leading to loss of beneficial oral species and pathogen colonization, ultimately to disease [50]