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10.1016/j.jvs.2017.10.091 59

Smokeless Smokeless tobacco use causes an immediate increase in heart rate and blood pressure due to the potent nicotine inside

Pharmacological and toxicological studies support the biological plausibility that nicotine contributes to acute cardiovascular events and accelerated atherogenesis

Symptoms begin to develop when the bodys oxygen demand increases and different symptoms may develop depending on which artery is narrowed: Unusual heartbeat and arrhythmia, Heart palpitations Pain or pressure in the upper body, such as the chest, arms, neck and jaw (this condition is commonly known as angina), Difficulty breathing, shortness of breath