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As the purpose of this study was to evaluate the effects of smoking reduction and cessation after COPD diagnosis on lung cancer development, we included only patients who were smoking before the diagnosis of COPD (Exam 1, N = 45,271)

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3.1.2 Cisplatin nephrotoxicity Cisplatin-induced nephrotoxicity is characterized by severe mitochondrial DNA (mtDNA) damage and bioenergetic dysfunction in RTECs (Hu et al., 2021)

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