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6 Boot and shoe manufacture and repair: Linked to increased risk of nasal cancer and leukaemia, due to exposure to suspected carcinogens such as leather dust, benzene and other solvents, yet the risk of cancer in shoe manufacturing may vary depending on the duration and level of exposure

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Thereby sustaining a systemic inflammatory milieu that promotes endothelial dysfunction, epithelial injury, and multi-organ failure (Nastase et al., 2018