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importantly, cumulative exposure (measured in pack-years) was strongly associated with fibrosis severity, with each additional pack-year tripling the likelihood of advanced fibrosis (adjusted OR per pack-year: 3.2

Since this product was first developed in 2004 in China as a tobacco cessation device, it has grown rapidly so that in 2013 the estimated market is about 1.5 billion as compared to 100 billion for tobacco sales

These analyses are described in more detail in the Supplementary Information

While the statement is true, this FDA action and the marketing that's likely to follow might suggest snuff is a safe product