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Cell culture studies showed that the chemical was directly tied to low HDL production

A new study presented in September 2021, by Gustaf Lyytinen, a clinician at Helsingborg Hospital and researcher at the Karolinska Institute in Stockholm and his team, found that nicotine-laden e-cigarettes raise a user's risk of blood clots, damage small blood vessels and can also raise heart rate and blood pressure

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They also found that high intake of folate, vitamin E and calcium were significantly associated with decreased risk of severe BV (Nugent score 9 and vaginal pH 5), with adjusted odds ratios of 0.40, 0.41, and 0.40, respectively (37)