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One study (Lewis-Esquerre et al., 2005) evaluated the TLFB method with adolescent smokers, and found it produced less digit bias than global reports, and that averaged consumption figures from TLFB correlated reasonably well with biochemical measures of smoking

The vapor may contain nicotine (the addictive drug in tobacco), flavoring, and other chemicals

And perhaps most importantly, for many users, cig-alikes simply did not deliver nicotine fast enough or in high enough quantity to provide an effective smoking substitute

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