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The severity of airway remodeling and inflammation was studied by determining alveolar enlargement, heart hypertrophy, inflammatory cells in the bronchoalveolar lavage fluid (BALF) and lung tissue and by analyzing the cytokine and chemokine profiles in the BALF of mice exposed to cigarette smoke for 20 weeks and 8 weeks after smoking cessation
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HTPs (heated tobacco products) have ER values around 0.1, suggesting a 10-fold reduction in the exposure to carcinogens and a likely reduction in cancer risk of the same order
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