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Dylans song had become a wistful wake-up call from a bygone phase of anti-racist struggle but Cookes Change still resonated, beyond the 1965 Watts riots against racial injustices, those in 1967 in Detroit and Newark, and with Martin Luther Kings 1968 assassination in Memphis, with the Black Power movements unfinished business with white America

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Here, we present CHANGE-seq-BE, a method for both sensitive and unbiased genome-wide discovery of gRNA-dependent base editor on-target and off-target sites, adapted from CHANGE-seq