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Stronger pouches (14mg+) actually last shorter because the higher nicotine concentration releases faster due to a larger gradient between pouch and mucosa

What should I do

Based on a power calculation using the Clincalc.com (ClinCalc LLC, Arlington Heights, IL, USA) sample size calculator with an assumed average BP of 120 mmHg, a BP variability of 5 mmHg, a clinically relevant difference of 6 mmHg, an enrollment ratio of 3, an alpha of 0.05, and a power of 80%, at least 28 participants, of which at least 7 in each of the cessation and relapse groups, were to be included

This neuromuscular blockade causes paralysis, bradycardia, and respiratory failure