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Skin wrinkles and premature aging may be caused by nicotine, other chemicals in cigarettes, smoking habits, and other things: Nicotine narrows blood vessels, which cuts off oxygen and nutrients from getting to skin cells

In the current examination, a strip and glass slab with a 500-g weight were applied for 20 s to ensure standard pressure, avoid contamination, and distribute stress, achieving uniformity in smooth specimens 22

Combine smoking with drinking, and that risk jumps even higher