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The challenges faced in carrying out these studies reflect those of observational research generally: assessment of the relevant exposures and outcomes with sufficient validity and precision, selection of an appropriate study design, identification of an appropriate and sufficiently large study population, and collection of information on other relevant factors that may confound or modify the association being studied

So I get to be around longer. Craig smiling with the quote I would recommend calling the Quit Line

Directly comparing the quit rates observed in a cohort of naturalistic JUUL users against quit rates observed in a trial characterized by tightly controlled participant inclusion/exclusion criteria, conditions of participation, pre-specified and homogeneous regimens of product use, and frequent contact with clinical staff, is therefore ill-advised

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