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In the United States, about 10% to 20% (20,000 to 40,000 cases) of lung cancer each year, develop in people who never smoked or smoked fewer than 100 cigarettes in their lifetime

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N Engl J Med (1994) 330:8115.10.1056/NEJM199403243301202 58 SandbornWJTremaineWJLeightonJALawsonGMZinsBJComptonRFet alNicotine tartrate liquid enemas for mildly to moderately active left-sided ulcerative colitis unresponsive to first-line therapy: a pilot study

However, these biomarkers can also be elevated in other fibrotic diseases, so some results from the respiratory tract rather than serum are more valuable for showing airway remodeling